Voyager did of course suffer terribly from the same problem as Quantum Leap before it. (and heck, it wasn’t new then . . . what was the first must-get-home show? The Time Tunnel?)  You knew the obvious short-cuts home would never work because that was the whole premise of the show.

The reverse was true in Enterprise. You knew the Xindi wouldn’t succeed in destroying the Earth and ending the series early, no matter how much you wanted it.